SIMPLYPROST®

Helps to promote prostate function and to enhance the health of male urinary system. Based on the extract of Serenoa repens, which contributes to the improvement of BHP symptoms.

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The prostate can grow, as a man gets older, applying increased pressure to the bladder and urethra, thus causing urinary problems. Benign Prostate hypertrophy is one of the most common conditions.

PROSTATE HYPERTROPHY – SYMPTOMS

Symptoms from the lower urinary tract are divided into those related to the accumulation of urine in the bladder and to those related to fluid excretion from the bladder, i.e. urination.

Symptoms related to the accumulation of urine:

| Frequent urination, when small amounts cause the urge to urinate regularly.
| Nocturia, waking up at night, to urinate.
| Urinary urgency
| Incontinence from urgency

Symptoms related to urine excretion:

| Reduction of urine flow
| Urinary hesitancy
| Intermittent urination.
| Loss of urine drops after the end of urination.
| A consistent need to urinate, even after recent urination.
| Complete inability to urinate, (urine retention)
| Bladder pain especially during urination (in cases of urinary tract infection), and hematuria. (usually in cases of urolithiasis)

Fatty Acids at high concentrations are recommended by the World Health Organization for the optimization of prostate function.

SIMPLYPROST contains essential oils from the fruit of Serenoa repens B. With a concentration higher than >90% in total fatty acids which contributes to the normal function of the prostate tissue and to the reduction of symptoms / inflammations of the lower urinary tract associated with benign prostatic hyperplasia.

| Fatty acids in high concentrations, as recommended by the World Health Organization

The properties of Serenoa Repens extract are confirmed by clinical studies. 1,2,3,4,5,6,7,8,9,10

SERENOA REPENS – MECHANISM OF ACTION

| Inhibition of 5-α reductase isoenzymes
| Inhibition of the activity of the estrogenic prostate receptor
| Anti-proliferative effect (prevents growth factors)
| Apoptotic action
| Anti-inflammatory action
| It acts on urinary bladder spasms

PHOSOLOGY: 1 tablet daily, consumed orally without chewing or breaking.

SIMPLYPROST is safe to take long-term, and is well tolerated.

SIMPLYPROST is a product of ANDROSYSTEMS SRL and is manufactured in Italy.

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REFERENCE
1. Gerber GS1, Kuznetsov D, Johnson BC, Burstein JD. Randomized, double-blind, placebo-controlled trial of saw palmetto in men with lower urinary tract symptoms. Urology. 2001 Dec;58(6):960-4; discussion 964-5
2. Hutchison A, Farmer R, Verhamme K, Berges R, Navarrete RV. The efficacy of drugs for the treatment of LUTS/BPH, a study in 6 European countries. Eur Urol. 2007 Jan;51(1):207-15; discussion 215-6. Epub 2006 Jun 27.
3. Hizli F1, Uygur MC. A prospective study of the efficacy of Serenoa repens, tamsulosin, and Serenoa repens plus tamsulosin treatment for patients with benign prostate hyperplasia. Int Urol Nephrol. 2007;39(3):879-86. Epub 2007 Jan 4.
4. Marks LS1, Partin AW, Epstein JI, Tyler VE, Simon I, Macairan ML, Chan TL, Dorey FJ, Garris JB, Veltri RW, Santos PB, Stonebrook KA, deKernion JB. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia.J Urol. 2000 May;163(5):1451-6.
5. Goepel M, Hecker U, Krege S, Rübben H, Michel MC.. Saw palmetto extracts potently and noncompetitively inhibit human alpha1-adrenoceptors in vitro. Prostate. 1999 Feb 15;38(3):208-15.
6. Pecoraro S, Annecchiarico A, Gambardella MC, Sepe G. [Efficacy of pretreatment with Serenoa repens on bleeding associated with transurethral resection of prostate]. Minerva Urol Nefrol. 2004 Mar;56(1):73-8.
7. Baron, A., Mancini, M., Caldwell, E., Cabrelle, A., Bernardi, P. and Pagano, F. (2009), Serenoa repens extract targets mitochondria and activates the intrinsic apoptotic pathway in human prostate cancer cells. BJU International, 103: 1275–1283. doi:10.1111/j.1464- 410X.2008.08266.
8. Agbabiaka TB1, Pittler MH, Wider B, Ernst E. Serenoa repens (saw palmetto): a systematic review of adverse events. Drug Saf. 2009;32(8):637-47. doi: 10.2165/00002018- 200932080-00003.
9. George FW, Russell DW, Wilson JD. Feed-forward control of prostate growth: Dihydrotestosterone induces expression of its own biosynthetic enzyme, steroid 5-alpha- reductase. Proc Natl Acad Sci 1991;88:8044-8047. 10. Mayumi Suzuki, Yoshihiko Ito, Tomomi Fujino, Masayuki Abe, Keizo Umegaki, Satomi Onoue, Hiroshi Noguchi, and Shizuo Yamada, Pharmacological effects of saw palmetto extract in the lower urinary tract. Acta Pharmacol Sin. 2009 Mar; 30(3): 271–281.

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